Network enrichment analysis: a powerful, multi-faceted tool

Posted on 11 October, 202411 October, 2024Tags , , , , , , , , ,   Leave a comment on Network enrichment analysis: a powerful, multi-faceted tool

Finding differential expressed genes or proteins can be challenging, especially when dealing with complex research questions like identifying molecular determinants of disease relapse years ahead. In the worst case no significant hits could be found at all. But fear not, there’s a solution: utilize Network Enrichment Analysis (NEA) to uncover pathways associated with your phenotype of interest. Unlike traditional methods, NEA is highly sensitive and specific, detecting compact, functionally relevant signaling and regulatory events. NEA has proven invaluable in a … Continue reading “Network enrichment analysis: a powerful, multi-faceted tool”

A deep-in preclinical study of a drug candidate finished with EviStat help.

Posted on 8 March, 202411 October, 2024Tags , , , , , , , , ,   Leave a comment on A deep-in preclinical study of a drug candidate finished with EviStat help.

Differential pathway activation can be detected and tested for significance with our network enrichment analysis tool (NEA). In this project, we studied tumor response to treatment with a candidate drug, VPS34 inhibitor SB02024 in the Renca mouse model. Even though the conventional differential expression analysis of data from the NanoString transcriptomics assay did not bring significant discoveries, the application of NEA was successful. When the transcriptome alterations were presented as sets of 30 most altered genes, NEA could demonstrate that … Continue reading “A deep-in preclinical study of a drug candidate finished with EviStat help.”